Pinealon

Pinealon Overview 

Pinealon is a three-amino-acid bioregulator. Peptide bioregulators are short peptides that enter cell nuclei to influence gene expression, enhancing organ function and regeneration. Pinealon supports brain health by protecting neurons, enhancing memory, regulating circadian rhythms, and promoting telomere health for may enhance both short- term and long-term memory by supporting the neural pathways involved in memory formation and retrieval. This could lead to better recall and information retention. In lab and animal models, Pinealon has shown signals like less cell damage, better cell survival, and signs that memory/behavior may improve. This is early-stage research—human evidence is limited. Research is ongoing and the claimed benefits are still emerging.

Pinealon Structure:

CAS Number: 175175-23-2.

Molecular Formula: C₁₅H₂₆N₆O₈.

Molecular Weight: 418.40 g/mol.

Parent Compound: Tripeptide Glu–Asp–Arg (L-glutamic acid + L-aspartic acid + L-arginine).

Monoisotopic Mass: 418.1812 Da (PubChem computed).

Synonyms:

• EDR peptide / Glu–Asp–Arg
• Glutamylaspartylarginine
• L-α-Glutamyl-L-α-aspartyl-L-arginine
• T-33 peptide

Research:

Scientists mostly look at Pinealon in cells and animal studies to see if it can help protect brain cells. Research explores whether it might:

• Help cells handle oxidative stress (the “rusting” that can damage cells)
• Protect the brain when there’s low oxygen (like in stroke models)
• Support learning, memory, and healthy aging in research animals
• Influence gene activity tied to brain plasticity (how the brain adapts)    

Research Areas:

• Brain cell protection
• Oxidative stress
• Low-oxygen injury (ischemia/hypoxia) models
• Aging/gerontology
• Gene-expression and neuroplasticity
• Learning/memory in animal studies
• Prenatal stress models

Research-only note: Pinealon is not FDA-approved for therapeutic use; published effects are primarily preclinical and exploratory.